Advanced Research on Staphylococcus aureus

From pioneering infection diagnostics to innovative therapies, explore the latest advancements in Staphylococcus aureus research that drive precision in infection management.

A human monoclonal antibody targeting the conserved staphylococcal antigen IsaA protects mice against Staphylococcus aureus bacteremia
  • Authors: van den Berg S, Bonarius HP, van Kessel KP, Elsinga GS, Kooi N, Westra H, Bosma T, van der Kooi-Pol MM, Koedijk DG, Groen H, van Dijl JM, Buist G, Bakker-Woudenberg IA.
  • Published in: PubMed, 2015.
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Differential epitope recognition in the immunodominant staphylococcal antigen A of Staphylococcus aureus by mouse versus human IgG antibodies.
  • Authors: Koedijk DGAM, Pastrana FR, Hoekstra H, Berg SVD, Back JW, Kerstholt C, Prins RC, Bakker-Woudenberg IAJM, van Dijl JM, Buist G.Sci Rep.
  • Published in: PubMed, 2017.
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Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe.
  • Authors: Romero Pastrana F, Thompson JM, Heuker M, Hoekstra H, Dillen CA, Ortines RV, Ashbaugh AG, Pickett JE, Linssen MD, Bernthal NM, Francis KP, Buist G, van Oosten M, van Dam GM, Thorek DLJ, Miller LS, van Dijl JM.Virulence.
  • Published in: PubMed, 2018.
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Multimodal imaging guides surgical management in a preclinical spinal implant infection model.
  • Authors: Zoller SD, Park HY, Olafsen T, Zamilpa C, Burke ZD, Blumstein G, Sheppard WL, Hamad CD, Hori KR, Tseng JC, Czupryna J, McMannus C, Lee JT, Bispo M, Romero Pastrana F, Raineri EJ, Miller JF, Miller LS, van Dijl JM, Francis KP, Bernthal NM.JCI Insight.
  • Published in: PubMed, 2017.
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Novel in vivo mouse model of shoulder implant infection.
  • Authors: Sheppard WL, Mosich GM, Smith RA, Hamad CD, Park HY, Zoller SD, Trikha R, McCoy TK, Borthwell R, Hoang J, Truong N, Cevallos N, Clarkson S, Hori KR, van Dijl JM, Francis KP, Petrigliano FA, Bernthal NM.J Shoulder Elbow Surg.
  • Published in: PubMed, 2020.
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Fighting Staphylococcus aureus infections with light and photoimmunoconjugates.
  • Authors: Bispo M, Anaya-Sanchez A, Suhani S, Raineri EJM, López-Álvarez M, Heuker M, Szymański W, Romero Pastrana F, Buist G, Horswill AR, Francis KP, van Dam GM, van Oosten M, van Dijl JM.JCI Insight.
  • Published in: PubMed, 2020.
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Time-resolved analysis of Staphylococcus aureus invading the endothelial barrier.
  • Authors: Raineri EJM, Yedavally H, Salvati A, van Dijl JM.Virulence.
  • Published in: PubMed, 2020.
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Empowering antimicrobial photodynamic therapy of Staphylococcus aureus infections with potassium iodide
  • Authors: Bispo M, Suhani S, van Dijl JM.J Photochem Photobiol B.
  • Published in: PubMed, 2021.
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Comparison of two fluorescent probes in preclinical non-invasive imaging and image-guided debridement surgery of Staphylococcal biofilm implant infections
  • Authors: Park HY, Zoller SD, Hegde V, Sheppard W, Burke Z, Blumstein G, Hamad C, Sprague M, Hoang J, Smith R, Romero Pastrana F, Czupryna J, Miller LS, López-Álvarez M, Bispo M, van Oosten M, van Dijl JM, Francis KP, Bernthal NM.Sci Rep.
  • Published in: PubMed, 2021.
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Comparison of two fluorescent probes.

Fluorescent probes enhance diagnosing implant-associated infections, offering non-invasive identification of organisms.
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Novel in vivo mouse model of shoulder implant infection.

Periprosthetic shoulder infections lack adequate animal models, challenging clinicians in guiding effective management strategies.
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Multimodal imaging guides surgical management.

Uncover the impact of our fully human monoclonal antibody, 1D9, in transforming the detection of spine implant infections.
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Targeted Imaging of Staphylococcus aureus Infections.
  • 12/26/2017

Explore our preclinical study unveiling the potential of fully-human monoclonal antibody 1D9. Precision-designed to target the immunodominant staphylococcal antigen A (IsaA), offering promising therapeutic insights.

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Illuminating Infections: The Power of Vanco-800CW

  • 2013

Dive into the potential of fluorescently labeled vancomycin (vanco-800CW) as a targeted tool for detecting Gram-positive bacterial infections. Explore innovative approaches to infection detection and diagnosis.

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