Precision theranostics for bacterial infections

Real-time bacterial imaging & theranostics

Localized theranostic solutions that revolutionize how bacterial infections are diagnosed and treated. Combine precision imaging with targeted interventions to improve patient outcomes.

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Detect → Target → Treat

Visualization of 1D9 tracers circulating within a blood vessel, targeting bacterial infections as part of a theranostic approach for real-time bacterial imaging and treatment.

Theranostic Platform Strategy

1
2A
2B
3
3D StaphMark vial
STEP 1
Tracer platform for PET imaging In-vivo (currently executed).
STEP 2A
Real-Time Fluorescence Imaging - Visualization In-vivo
STEP 2B
Bioluminescence Point of Care Synovial Fluid / Nose Swab - Ex-vivo
3D StaphMark vial
STEP 3
Photodynamic Therapy - (Radio) Theranostic & Radio theranostic treatment - In-vivo

Bacterial imaging & theranostics (In Vivo)

Experience the future of infection management with targeted imaging and treatment solutions that guide critical surgical decisions.

3D PET-CT scan
PET-CT surgical intervention of mouse
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Clinical Application 1

Detection with 89Zirconium-labeled Antibody

Currently in Phase 0 development, our 89Zirconium-labeled 1D9 antibody enables precise PET imaging of bacterial infections in vivo. This real-time imaging helps localize infections, allowing surgeons to make accurate decisions.

89Zirconium antibody improves real-time detection for surgical precision.

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Clinical Application 2

Fluorescent Labeling

We are also exploring fluorescent labeling for use in near-infrared imaging during surgeries. This approach enhances the visibility of bacteria in real-time, improving the precision of infection detection.

  • Sensitivity: 100%
  • Specificity: Detects approximately 2.5 x 10⁴ Staphylococcus aureus bacteria per mm³

Fluorescent labeling increases visibility for targeted intervention.

Series of images showing control, PET-CT, NIR, and post-surgery views of 89Zr-NIR680-1D9 antibody targeting Staphylococcus aureus infection, demonstrating precise infection localization and guided intervention.

Zirconium-based near-infrared agents for precision diagnosis and image-guided surgery. Administered through a single bolus injection, our zirconium-based agents offer exceptional precision for bacterial detection and surgical guidance.

Luminescence and fluorescence imaging of Staphylococcus aureus treatment solution under different light conditions and concentrations, showing response at 0, 20, 40, and 80 µg/mL.
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Clinical Application 3

Antimicrobial Photodynamic Therapy

Our preclinical research demonstrates the effectiveness of 1D9 when conjugated with IRDye700DX and used with photodynamic therapy. This method can precisely eradicate MRSA without harming healthy tissue, offering a novel solution for difficult-to-treat infections.

aPDT is precise bacterial eradication without harming healthy cells.

Ex Vivo Applications of StaphMark

Bringing precision and speed to diagnostics outside the body with the point of care applications.

Ex vivo synovial fluid analysis and nasal swab testing for Staphylococcus aureus detection, showing gloved hands collecting samples.

Synovial fluid analysis

We are developing point-of-care diagnostics using the 1D9 antibody combined with bioluminescence for rapid detection of S. aureus infections in synovial fluid (from joint samples). This innovation significantly reduces the time to diagnosis, from days to mere minutes.

Nasal swab testing

We are also developing rapid nasal swab tests to identify Staphylococcus aureus carriers. Early detection in hospital settings will help prevent the spread of these infections.